Dr. Jean-Jacques Dugoua Naturopathic Doctor PhD in Pharmacy

Top-selling drugs: interactions with natural and dietary supplements

By Dr. JJ Dugoua ND PhD

info@askdrjj.com

 

In 2010, the top prescriptions in the Unites States were:

 

 

  1. Hydrocodone (combined with acetaminophen)     131.2 million
  2. Generic Zocor (simvastatin)            94.1 million
  3. Lisinopril (Prinivil and Zestril)        87.4 million
  4. Generic Synthroid (levothyroxine sodium)            70.5 million
  5. Generic Norvasc (amlodipine besylate)      57.2 million
  6. Generic Prilosec (omeprazole)        53.4 million
  7. Azithromycin (Z-Pak and Zithromax)        52.6 million
  8. Amoxicillin             52.3 million
  9. Generic Glucophage (metformin)   48.3 million
  10. Hydrochlorothiazide         47.8 million

 

 

In 2010, the top-selling drugs in the United States were:

  1. Lipitor (atorvastatin)           $7.2 billion
  2. Nexium (esomeprazole)      $6.3 billion
  3. Plavix (clopidogrel disulphate)       $6.1 billion
  4. Advair Diskus (fluticasone + salmeterol)   $4.7 billion
  5. Abilify (aripiprazole)           $4.6 billion
  6. Seroquel (quetiapine)          $4.4 billion
  7. Singulair (Montelukast)      $4.1 billion
  8. Crestor (rosuvastatin)          $3.8 billion
  9. Actos (Pioglitazone)           $3.5 billion
  10. Epogen (epoetin alfa)        $3.3 billion

 

 

The purpose of this talk is to review clinical reports of interactions and theoretical interactions between dietary supplements and the drugs listed above.  The mechanism of drug interactions will be discussed, including pharmacokinetics (drug absorption, distribution, elimination and excretion) in particular cytochrome p450 enzymes.